Evaluation of biocompatible osteoconductive polymer activity and biocompatibility for minor oral surgery in animals and humans.

The speed of recovery with and biocompatibility of biocompatible osteoconductive polymer used for minor oral surgery were investigated in animals and humans. Histological and radiological follow-up of graft sites and experimental mandibular bone loss was performed in 20 rabbits. Evaluation of X-rays showed no notable difference between the treated and control animals; however, biopsies 60 days after surgery showed that those animals treated with biocompatible osteoconductive polymer did not have any interposition of connective tissue between the polymer and the new bony tissue whereas the control samples did. Radiographic follow-up of the human patients at 30 and 60 days following molar extraction showed more bone regeneration in all patients treated with the polymer compared to the controls. The results showed that the use of biocompatible osteoconductive polymer to fill secondary surgical extraction cavities provided fast prosthetic rehabilitation for the patients.