Synchronous primary neoplasia in patients with oropharyngeal cancer: Impact of tumor HPV status. A GETTEC multicentric study.
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Milliet Florent, Bozec Alexandre, Schiappa Renaud, Viotti Julien, Modesto Anouchka, Dassonville Olivier, Poissonnet Gilles, Guelfucci Bruno, Bizeau Alain, Vergez Sebastien, Dupret-Bories Agnes, Garrel Renaud, Fakhry Nicolas, Santini Laure, Lallemant Benjamin, Chambon Guillaume, Sudaka Anne, Peyrade Frederic, Saada-Bouzid Esma, Benezery Karen, Jourdan-Soulier Florence, Chapel Françoise, Sophie Ramay Anne, Roger Pascal, Galissier Thibault, Coste Valérie, Ben Lakdar Aicha, Guerlain Joanne, Temam Stephane, Mirghani Haitham, Gorphe Phillipe, Chamorey Emmanuel, Culié Dorian
Аннотация
MATERIAL AND METHODS: All OPSCC patients treated from 2009 to 2014 were included in this multicentric retrospective study. Univariate analyses were conducted using Chi-2 and Fisher exact tests. For multivariate analyses, all variables associated with a p ≤ 0.10 in univariate analysis were included in logistic regression models.
RESULTS: Among the 1291 patients included in this study, 75 (5.8%) displayed a SPN which was preferentially located in the upper aerodigestive tract, lung and esophagus. Comorbidity level (p = 0.03), alcohol (p = 0.005) and tobacco (p = 0.01) consumptions, and p16 tumor status (p < 0.0001) were significant predictors of SPN. In multivariate analysis, p16+ status was significantly associated with a lower risk of SPN (OR = 0.251, IC95% [0.133;0.474]). Patients with a SPN were more frequently referred for non-curative treatment (p = 0.02). In patients treated with curative intent, there was no impact of SPN on the therapeutic strategy (surgical vs. non-surgical treatment). We observed no overall survival differences between patients with or without SPN.
CONCLUSION: P16 tumor status is the main predictive factor of SPN in OPSCC patients. This study provides crucial results which should help adapt the initial work-up and the global management of OPSCC patients.