Upfront surgery or definitive radiotherapy for patients with p16-negative oropharyngeal squamous cell carcinoma. A GETTEC multicentric study.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Culié Dorian, Viotti Julien, Modesto Anouchka, Schiappa Renaud, Chamorey Emmanuel, Dassonville Olivier, Poissonnet Gilles, Guelfucci Bruno, Bizeau Alain, Vergez Sebastien, Dupret-Bories Agnes, Garrel Renaud, Fakhry Nicolas, Santini Laure, Lallemant Benjamin, Chambon Guillaume, Sudaka Anne, Peyrade Frederic, Saada-Bouzid Esma, Benezery Karen, Jourdan-Soulier Florence, Chapel Françoise, Ramay Anne Sophie, Roger Pascal, Galissier Thibault, Coste Valérie, Ben Lakdar Aicha, Guerlain Joanne, Temam Stephane, Mirghani Haitham, Gorphe Phillipe, Bozec Alexandre
Аннотация
MATERIAL AND METHOD: All p16-negative OPSCCs treated from 2009 to 2014 in 7 tertiary-care centers were included in this retrospective study and were classified according to the therapeutic strategy: surgical strategy (surgery ± adjuvant radiotherapy and chemotherapy) vs. non-surgical strategy (definitive radiotherapy ± chemotherapy). Patients not eligible for surgery (unresectable tumor, poor general-health status) were excluded. Univariate, multivariate and propensity score matching analyses were performed to compare overall (OS), disease-specific (DSS) and recurrence-free survival (RFS).
RESULTS: Four hundred seventy-four (474) patients were included in the study (surgical group: 196; non-surgical group: 278). Five-year OS, DSS and RFS were 76.5, 81.3 and 61.3%, respectively, in the surgical group and 49.9, 61.8 and 43.4%, respectively, in the non-surgical group. The favorable impact of primary surgical treatment on oncologic outcomes was statistically significant after multivariate analysis. This effect was more marked for locally-advanced than for early-stage tumors. Propensity score matching analysis confirmed the prognostic impact of primary surgical treatment for RFS.
CONCLUSION: Therapeutic strategy is an independent prognostic factor in patients with p16-negative OPSCC and primary surgical treatment is associated with improved OS, DSS and RFS. These results suggest that surgical strategy is a reliable option for advanced stage OPSCC.