Journal of hypertension · 2025
Catheter-based ultrasound nerve stimulation and selective renal denervation: a preliminary case series study.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Qian Jun, Zhou Zhongzheng, Zheng Yiwen, Rong Shunkang, Yao Yuanqing, Xiong Bo, Dai Weiran, Du Yun, Liu Han, Sha Wei, Liu Dichuan, Deng Changming, Huang Jing
Аннотация
This study aimed to evaluate the feasibility and efficacy of a catheter-based ultrasound renal denervation (RDN) system for nerve mapping guided RDN and treatment efficacy verification. A total of five patients were sequentially enrolled. Low-power pulsed ultrasound stimulation was applied at the distal, middle and proximal segments of the renal arteries, in both head-foot and abdomen-back directions. Ultrasound RDN was selectively performed at sites where SBP increased by at least 5 mmHg following stimulation. Supplementary RDN was conducted at any sites exhibiting an SBP increase of at least 5 mmHg after re-stimulation. A total of 60 directional stimulations were applied across 10 renal arteries, with 70% of these directions received ultrasound RDN. The daytime ambulatory SBP decreased from 151 to 130 mmHg after two months. These findings indicate that catheter-based ultrasound renal mapping guided RDN might feasible and could offer a more targeted approach to the RDN procedure.