Impact of Low-Dose Computed Tomography Findings on Cigarette Smoking Cessation Among High-Risk Adults Participating in Lung Cancer Screening.
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Katsampouris Evangelos, Bhamani Amyn, Bojang Fanta, Dickson Jennifer L, Hall Helen, Horst Carolyn, Verghese Priyam, Creamer Andrew, Prendecki Ruth, Khaw Chuen, Tisi Sophie, McCabe John, Gyertson Kylie, Hacker Anne-Marie, Farrelly Laura, Navani Neal, Hackshaw Allan, SUMMIT Consortium, Janes Sam M, Quaife Samantha L, Janes Sam M, Dickson Jennifer L, Horst Carolyn, Tisi Sophie, Hall Helen, Verghese Priyam, Creamer Andrew, Callender Thomas, Prendecki Ruth, Bhamani Amyn, Ruparel Mamta, Hackshaw Allan, Farrelly Laura, Teague Jon, Mullin Anne-Marie, Chan Kitty, Sarpong Rachael, Suresh Malavika, Quaife Samantha L, Nair Arjun, Devaraj Anand, Gyertson Kylie, Bowyer Vicky, El-Emir Ethaar, Airebamen Judy, Cotton Alice, Phua Kaylene, Murali Elodie, Mehta Simranjit, Zylstra Janine, Parry-Billings Karen, Ife Columbus, Neville April, Robinson Paul, Green Laura, Hanif Zahra, Kiconco Helen, McEwen Ricardo, Arancon Dominique, Beech Nicholas, Ovayolu Derya, Hosein Christine, Enes Sylvia Patricia, Neville Qin April, Rowlands Jane, Samson Aashna, Patel Urja, Hoque Fahmida, Pervez Hina, Nnorom Sofia, Miah Moksud, McKee Julian, Clark Mark, Eng Jeannie, Bojang Fanta, Levermore Claire, Patel Anant, Lock Sara, Banka Rajesh, Bhowmik Angshu, Ekeowa Ugo, Mangera Zaheer, Ricketts William M, Navani Neal, O'Shaughnessy Terry, Cash Charlotte, Taylor Magali, Hare Samanjit, Aziz Tunku, Ellis Stephen, Edey Anthony, Robinson Graham, Villanueva Alberto, Robbie Hasti, Stefan Elena, Sayer Charlie, Screaton Nick, Nundlall Navinah, Gallagher Lyndsey, Crossingham Andrew, Buchan Thea, Limani Tanita, Gowers Kate, Davies Kate, McCabe John, Jacob Joseph, Sennett Karen, Anastasiadis Tania, Perugia Andrew, Rusius James, Bellingan Geoff, Browne Maureen, Hellier Eleanor, Nestor Catherine
Аннотация
AIMS AND METHODS: 13 035 individuals, aged 55-77 years, attended a lung health check appointment, as part of a prospective observational cohort study (the SUMMIT Study), prior to undergoing a baseline LDCT scan. Logistic regressions examined the likelihood of smoking cessation at a 1-year follow-up appointment and its association with LDCT findings.
RESULTS: 12.6% (n = 647/5135) of individuals self-reported smoking cessation at 1-year follow-up. Higher odds of quitting were found in those receiving indeterminate pulmonary nodule findings requiring a 3-month interval LDCT (aOR = 1.27; 1.01, 1.61), those with urgent findings requiring referral to secondary care (aOR = 1.55; 1.05, 2.32), and those with a possible new chronic obstructive pulmonary disease diagnosis (aOR = 1.60; 1.23, 2.06), compared to those receiving no actionable LDCT findings. Older age, Asian ethnic background, current high smoking intensity, motivation and number of quit attempts, and low nicotine dependence were associated with increased odds of quitting.
CONCLUSIONS: Individuals currently smoking, at high lung cancer risk, participating in LDCT screening, and receiving incidental findings requiring a 1-year interval LDCT or primary care follow-up might therefore need additional behavioral support to quit. Tailored communication strategies depending on the severity of the LDCT findings, including additional behavioral support for those with less clinical concerning or negative findings, could increase quit rates and reduce smoking-related morbidity.
IMPLICATIONS: This study reports high odds of self-reported complete smoking cessation in adults who currently smoked after receiving their LDCT findings. Though the impact of specific types of LDCT findings on smoking cessation was positive for high lung cancer risk individuals, reception of incidental findings could potentially be perceived as less severe to encourage individuals who currently smoked to quit. Clearly communicating the severity of LDCT findings along with the delivery of behavioral smoking cessation support targeted to high-risk individuals may increase their chances of complete smoking cessation and reduce lung cancer mortality.