European journal of cancer (Oxford, England : 1990) · 2025
Validation of the 9th Tumor, Node, and Metastasis Staging System for Patients with Surgically Resected Non-Small Cell Lung Cancer.
СтатьяВалидационное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Kim Shia, Ahn Yura, Lee Geun Dong, Choi Sehoon, Kim Hyeong Ryul, Kim Yong-Hee, Kim Dong Kwan, Park Seung-Il, Yun Jae Kwang
Аннотация
INTRODUCTION: The ninth edition of the tumor, node, and metastasis (TNM) classification system was recently published by the International Association for the Study of Lung Cancer staging project. This study aimed to validate the ninth edition of the TNM staging system, and compare its discrimination power with that of the eighth edition.
METHODS: Patients who had undergone complete resection with systematic lymph node dissection for non-small cell lung cancer (NSCLC) were included in this retrospective analysis. Significant differences among adjacent TNM stage groupings were identified using a Cox regression model. The concordance index (C-index), Akaike Information Criterion (AIC), and R2 were calculated to assess the discriminatory power of the two classification systems.
RESULTS: A total of 7429 patients (4325 male; interquartile range, 57-70 years) were analyzed. The median follow-up duration was 50.4 months (interquartile range, 18-69 months). Survival curves within adjacent stage groupings created according to the ninth edition exhibited significant differences for all groups when divided according to the clinical or pathological stage. Compared with that of the eighth edition, the ninth edition demonstrated an improved discriminatory ability, as evidenced by a higher C-index (0.769 vs. 0.767), lower AIC (26,820 vs. 26,851), and higher R2 (0.164 vs. 0.160) values.
CONCLUSIONS: Compared to the eighth edition of the TNM staging system, the ninth edition demonstrated improved prognostic accuracy and superior discriminatory ability for clinical and pathological stages.
METHODS: Patients who had undergone complete resection with systematic lymph node dissection for non-small cell lung cancer (NSCLC) were included in this retrospective analysis. Significant differences among adjacent TNM stage groupings were identified using a Cox regression model. The concordance index (C-index), Akaike Information Criterion (AIC), and R2 were calculated to assess the discriminatory power of the two classification systems.
RESULTS: A total of 7429 patients (4325 male; interquartile range, 57-70 years) were analyzed. The median follow-up duration was 50.4 months (interquartile range, 18-69 months). Survival curves within adjacent stage groupings created according to the ninth edition exhibited significant differences for all groups when divided according to the clinical or pathological stage. Compared with that of the eighth edition, the ninth edition demonstrated an improved discriminatory ability, as evidenced by a higher C-index (0.769 vs. 0.767), lower AIC (26,820 vs. 26,851), and higher R2 (0.164 vs. 0.160) values.
CONCLUSIONS: Compared to the eighth edition of the TNM staging system, the ninth edition demonstrated improved prognostic accuracy and superior discriminatory ability for clinical and pathological stages.