[Pathogenetic and clinical significance of pentagastrin stimulation of gastric secretion in the active phase of peptic ulcer].

The gastric secretion with pentagastrin was studied in 214 subjects (130 with duodenal ulcer, 20 with double localization--in duodenum and stomach, 32 with gastric ulcer and 32--healthy). A different gastric secretory characteristic was found and the problem raised as regards the differentiated therapeutic and surgical approach in the separate tyoes of ulcer disease. The origination and clinical course of the duodenal ulcer and the ulcer with double localization are admitted to depend most likely and to a greater extent, on the gastric secretion rate. The duration of the active duodenal ulcer probably has no substantial effect on the enhanced secretory function of the stomach in the course of many years. The indices of secretion and acid elimination in single gastric ulcers are significantly diminished.