The European journal of surgery = Acta chirurgica · 1992
Effect of proximal gastric vagotomy on the activity of hydrogen, potassium-stimulated ATPase in the gastric mucosa of patients with duodenal ulcer.
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Leibur M, Kengsepp A T, Sibul U, Truve R
Аннотация
OBJECTIVE: To find out if there was a correlation between hydrogen, potassium stimulated ATPase (H,K-ATPase) activity and gastric acid secretion in patients with duodenal ulcers after proximal gastric vagotomy.
DESIGN: Retrospective study.
SETTING: Regional referral center.
SUBJECTS: 61 patients with chronic duodenal ulcers divided into three groups: patients who had not been operated on but had exacerbations of their symptoms (n = 39): those who had been treated successfully by proximal gastric vagotomy either less than 1 year ago (n = 7) or greater than or equal to 1 year ago (n = 9): and those patients who presented with recurrent ulceration after proximal gastric vagotomy (n = 6).
MAIN OUTCOME MEASURES: Measurement of H,K-ATPase activity and gastric acid secretion.
RESULTS: There was a decrease in H,K-ATPase activity after effective vagotomy, and enzyme activity was the lowest in patients who had been operated on 1 year ago. Both H,K-ATPase and gastric acid secretion were decreased by proximal gastric vagotomy.
CONCLUSION: There may be a gradual recovery of gastric H,K-ATPase activity with time after proximal gastric vagotomy.
DESIGN: Retrospective study.
SETTING: Regional referral center.
SUBJECTS: 61 patients with chronic duodenal ulcers divided into three groups: patients who had not been operated on but had exacerbations of their symptoms (n = 39): those who had been treated successfully by proximal gastric vagotomy either less than 1 year ago (n = 7) or greater than or equal to 1 year ago (n = 9): and those patients who presented with recurrent ulceration after proximal gastric vagotomy (n = 6).
MAIN OUTCOME MEASURES: Measurement of H,K-ATPase activity and gastric acid secretion.
RESULTS: There was a decrease in H,K-ATPase activity after effective vagotomy, and enzyme activity was the lowest in patients who had been operated on 1 year ago. Both H,K-ATPase and gastric acid secretion were decreased by proximal gastric vagotomy.
CONCLUSION: There may be a gradual recovery of gastric H,K-ATPase activity with time after proximal gastric vagotomy.