Cancer research · 2002
Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Oka Takashi, Ouchida Mamoru, Koyama Maho, Ogama Yoichiro, Takada Shinichi, Nakatani Yoko, Tanaka Takehiro, Yoshino Tadashi, Hayashi Kazuhiko, Ohara Nobuya, Kondo Eisaku, Takahashi Kiyoshi, Tsuchiyama Junjiro, Tanimoto Mitsune, Shimizu Kenji, Akagi Tadaatsu
Аннотация
High-frequent silencing of hematopoietic cell-specific protein-tyrosine phosphatase SHP1 gene by promoter methylation was detected in various kinds of leukemias and lymphomas, as well as in many hematopoietic cell lines, which is supported by our previous observation of strong decrease of SHP1 mRNA and protein. The promoter methylation of the SHP1 gene was clearly correlated with the clinical stage. Loss of heterozygosity with microsatellite markers near the SHP1 gene was shown in 79% of informative acute lymphoblastic leukemia cases. These results suggest that functional loss of SHP1 is associated with the pathogenesis of leukemias/lymphomas.
Предметные рубрики MeSH
Acute DiseaseBase SequenceDNA MethylationGene Expression Regulation, LeukemicGene SilencingHumansIntracellular Signaling Peptides and ProteinsLeukemiaLeukemia, Myelogenous, Chronic, BCR-ABL PositiveLeukemia, MyeloidLoss of HeterozygosityLymphoma, T-CellMolecular Sequence DataPrecursor Cell Lymphoblastic Leukemia-LymphomaProtein Tyrosine Phosphatase, Non-Receptor Type 6Protein Tyrosine PhosphatasesRNA, MessengerTumor Cells, Cultured