Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2004
[A possible preneoplastic lesion of colorectum].
Аннотация на английскомСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Lai Mao-de, Huang Qiong, Parwaresch Reza
Аннотация
OBJECTIVE: To investigate KiA10 expression in colorectal cancer and related colorectal tissues.
METHODS: KiA10 expression was detected by immunohistochemistry in tissue specimens from 101 cases of colorectal cancer and matched cut-margin mucosa and mucosa adjacent to cancers; also in colorectal specimens from 16 cases of ulcerative colitis, 16 of Crohn's disease and 3 healthy subjects.
RESULT: The positive rate of KiA10 expression in colorectal cancer was 14.85% (15/101); KiA10 positive crypts was demonstrated in 18 cut-margin mucosa and 18 mucosa adjacent to tumors respectively, but they were not matched with each other.
CONCLUSION: The results suggest that KiA10-positive crypts of the colon might be a preneoplastic lesion.
METHODS: KiA10 expression was detected by immunohistochemistry in tissue specimens from 101 cases of colorectal cancer and matched cut-margin mucosa and mucosa adjacent to cancers; also in colorectal specimens from 16 cases of ulcerative colitis, 16 of Crohn's disease and 3 healthy subjects.
RESULT: The positive rate of KiA10 expression in colorectal cancer was 14.85% (15/101); KiA10 positive crypts was demonstrated in 18 cut-margin mucosa and 18 mucosa adjacent to tumors respectively, but they were not matched with each other.
CONCLUSION: The results suggest that KiA10-positive crypts of the colon might be a preneoplastic lesion.