Blood · 2008
CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Truman Lucy A, Ford Catriona A, Pasikowska Marta, Pound John D, Wilkinson Sarah J, Dumitriu Ingrid E, Melville Lynsey, Melrose Lauren A, Ogden Carol Anne, Nibbs Robert, Graham Gerard, Combadiere Christophe, Gregory Christopher D
Аннотация
Cells undergoing apoptosis are efficiently located and engulfed by phagocytes. The mechanisms by which macrophages, the professional scavenging phagocytes of apoptotic cells, are attracted to sites of apoptosis are poorly defined. Here we show that CX3CL1/fractalkine, a chemokine and intercellular adhesion molecule, is released rapidly from apoptotic lymphocytes, via caspase- and Bcl-2-regulated mechanisms, to attract macrophages. Effective chemotaxis of macrophages to apoptotic lymphocytes is dependent on macrophage fractalkine receptor, CX3CR1. CX3CR1 deficiency caused diminished recruitment of macrophages to germinal centers of lymphoid follicles, sites of high-rate B-cell apoptosis. These results provide the first demonstration of chemokine/chemokine-receptor activity in the navigation of macrophages toward apoptotic cells and identify a mechanism by which macrophage infiltration of tissues containing apoptotic lymphocytes is achieved.