Journal of the American Academy of Dermatology · 2007
Persistent agmination of lymphomatoid papulosis: an equivalent of limited plaque mycosis fungoides type of cutaneous T-cell lymphoma.
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Heald Peter, Subtil Antonio, Breneman Deborah, Wilson Lynn D
Аннотация
BACKGROUND: Lymphomatoid papulosis (LyP) is a self-healing eruption in the spectrum of CD30+ lymphoproliferative disorders. The most common lymphoproliferative disorder associated with LyP is the most common form of cutaneous T-cell lymphoma: mycosis fungoides.
OBJECTIVE: We sought to describe a distinct entity on the spectrum of CD30+ lymphoproliferative disorders.
RESULTS: Seven patients presented with similar findings. Within a well-circumscribed area, the size and location of a patch of mycosis fungoides, these patients had continual eruptions of papulonodules that were histologically typical of LyP. The localized areas of involvement were treated as oligolesional mycosis fungoides and long-standing remissions occurred even after years of experiencing continuous localized eruptions. The clinical and histologic findings are reviewed and presented in a way to further the identification of patients with this entity.
LIMITATIONS: This distinct entity is only defined by 7 patients.
CONCLUSION: The agmination of LyP-like papulonodules confined to a discrete circumscribed area is a distinct clinical subset within the spectrum of CD30+ lymphoproliferative disorders. The behavior of this entity is that of a progressive lymphoma that warrants therapy.
OBJECTIVE: We sought to describe a distinct entity on the spectrum of CD30+ lymphoproliferative disorders.
RESULTS: Seven patients presented with similar findings. Within a well-circumscribed area, the size and location of a patch of mycosis fungoides, these patients had continual eruptions of papulonodules that were histologically typical of LyP. The localized areas of involvement were treated as oligolesional mycosis fungoides and long-standing remissions occurred even after years of experiencing continuous localized eruptions. The clinical and histologic findings are reviewed and presented in a way to further the identification of patients with this entity.
LIMITATIONS: This distinct entity is only defined by 7 patients.
CONCLUSION: The agmination of LyP-like papulonodules confined to a discrete circumscribed area is a distinct clinical subset within the spectrum of CD30+ lymphoproliferative disorders. The behavior of this entity is that of a progressive lymphoma that warrants therapy.