Blood · 2013
Autologous stem cell transplantation for enteropathy-associated T-cell lymphoma: a retrospective study by the EBMT.
Оценочное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Jantunen Esa, Boumendil Ariane, Finel Herve, Luan Jian-Jian, Johnson Peter, Rambaldi Alessandro, Haynes Andrew, Duchosal Michel A, Bethge Wolfgang, Biron Pierre, Carlson Kristina, Craddock Charles, Rudin Claudius, Finke Jurgen, Salles Gilles, Kroschinsky Frank, Sureda Anna, Dreger Peter, Lymphoma Working Party of the EBMT
Аннотация
Enteropathy-associated T-cell lymphoma (EATL) is a rare subtype of peripheral T-cell lymphomas with a poor prognosis. Autologous stem cell transplantation (ASCT) was retrospectively evaluated as a consolidation or salvage strategy for EATL. The analysis included 44 patients who received ASCT for EATL between 2000 and 2010. Thirty-one patients (70%) were in first complete or partial remission at the time of the ASCT. With a median follow-up of 46 months, relapse incidence, progression-free survival, and overall survival were 39%, 54%, and 59% at 4 years, respectively, with only one relapse occurring beyond 18 months posttransplant. There was a trend for better survival in patients transplanted in first complete or partial remission at 4 years (66% vs 36%; P = .062). ASCT is feasible in selected patients with EATL and can yield durable disease control in a significant proportion of the patients.