Nihon rinsho. Japanese journal of clinical medicine · 2009
[Gastric MALT lymphoma: recent topics regarding treatment and genetic aberrations].
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Nakamura Shotaro, Matsumoto Takayuki, Iida Mitsuo
Аннотация
The recent topics in the treatment and genetic aberrations of gastric MALT lymphoma were reviewed. The chromosomal translocation t(11;18) (q21;q21)/API2-MALT1 has been frequently detected not only in gastric MALT lymphoma cases, but also in gastric diffuse large B-cell lymphoma (DLBCL) cases in two studies. Conversely, IGH-involved translocations, including t(3;14) (p14;q32)/FOXP1-IGH, are rarely seen in gastric MALT lymphoma. Several large-scaled clinical series have revealed that Helicobacter pylori eradication therapy is the optimal first-line treatment for patients with gastric MALT lymphoma, which leads to a favorable long-term outcome. A number of modalities and/or regimens, including chemotherapy, immunotherapy, and radioimmuotherapy, have been developed as the second-line treatments for patients not responding to eradication therapy.