Leukemia · 2022
Diagnostics in Waldenström's macroglobulinemia: a consensus statement of the European Consortium for Waldenström's Macroglobulinemia.
СтатьяПоддержка исследования: вне правительства СШАConsensus StatementНазвание и аннотация: Перевод пока не подготовлен
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Dogliotti Irene, Jiménez Cristina, Varettoni Marzia, Talaulikar Dipti, Bagratuni Tina, Ferrante Martina, Pérez José, Drandi Daniela, Puig Noemí, Gilestro Milena, García-Álvarez María, Owen Roger, Jurczak Wojciech, Tedeschi Alessandra, Leblond Veronique, Kastritis Efstathios, Kersten Marie José, D'Sa Shirley, Kaščák Michal, Willenbacher Wolfgang, Roccaro Aldo M, Poulain Stephanie, Morel Pierre, Kyriakou Charalampia, Fend Falko, Vos Josephine M I, Dimopoulos Meletios A, Buske Christian, Ferrero Simone, García-Sanz Ramón
Аннотация
The diagnosis of Waldenström's macroglobulinemia (WM), an IgM-associated lymphoplasmacytic lymphoma, can be challenging due to the different forms of disease presentation. Furthermore, in recent years, WM has witnessed remarkable progress on the diagnostic front, as well as a deeper understanding of the disease biology, which has affected clinical practice. This, together with the increasing variety of tools and techniques available, makes it necessary to have a practical guidance for clinicians to perform the initial evaluation of patients with WM. In this paper, we present the consensus recommendations and laboratory requirements for the diagnosis of WM developed by the European Consortium of Waldenström's Macroglobulinemia (ECWM), for both clinical practice as well as the research/academical setting. We provide the procedures for multiparametric flow cytometry, fluorescence in situ hybridization and molecular tests, and with this offer guidance for a standardized diagnostic work-up and methodological workflow of patients with IgM monoclonal gammopathy of uncertain significance, asymptomatic and symptomatic WM.