Hepato-gastroenterology · 2003
The role of preoperative phenylalanine breath test in hepatectomy.
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Kobayashi Takashi, Imamura Hiroshi, Takayama Tadatoshi, Makuuchi Masatoshi
Аннотация
BACKGROUND/AIMS: The phenylalanine breath test may serve as a liver function test, although its clinical usefulness has never been clarified. This study aimed to evaluate the role of preoperative phenylalanine breath test in patients undergoing hepatectomy.
METHODOLOGY: Twenty-seven patients undergoing hepatectomy were studied. The PBT30 (phenylalanine excretion ratio at 30 min) was measured after oral administration of 100 mg of L-[1-(13)C]-phenylalanine. Postoperative mortality and morbidity were compared with the value of PBT30, ICGR15 (plasma retention rate of indocyanine green at 15 min), Child-Pugh score, and other blood chemical tests together with operative factors. Independent factors contributing to postoperative mortality and morbidity were evaluated by multiple logistic regression analysis.
RESULTS: Postoperative mortality and morbidity rates were 0 and 25.9%, respectively. PBT30 and ICGR15 values were significantly different between the groups with and without postoperative complication, and these two parameters independently contributed to prediction of postoperative complication.
CONCLUSIONS: PBT30 is a clinically useful predictor for postoperative complication in patients undergoing hepatectomy.
METHODOLOGY: Twenty-seven patients undergoing hepatectomy were studied. The PBT30 (phenylalanine excretion ratio at 30 min) was measured after oral administration of 100 mg of L-[1-(13)C]-phenylalanine. Postoperative mortality and morbidity were compared with the value of PBT30, ICGR15 (plasma retention rate of indocyanine green at 15 min), Child-Pugh score, and other blood chemical tests together with operative factors. Independent factors contributing to postoperative mortality and morbidity were evaluated by multiple logistic regression analysis.
RESULTS: Postoperative mortality and morbidity rates were 0 and 25.9%, respectively. PBT30 and ICGR15 values were significantly different between the groups with and without postoperative complication, and these two parameters independently contributed to prediction of postoperative complication.
CONCLUSIONS: PBT30 is a clinically useful predictor for postoperative complication in patients undergoing hepatectomy.