Transplantation proceedings · 2019
Rapid Decrease in Liver Graft Steatosis in the Early Post-transplant Period: A Blinded and Randomized Study.
Clinical StudyСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Mangus Richard S, Davis Jason P, Lin Jingmei
Аннотация
AIMS: Previous research suggests a rapid post-transplant decrease in liver steatosis. With increased use of liver grafts with steatosis, better understanding of this post-transplant change will facilitate successful liver transplantation. This study compares liver reperfusion biopsies with early post-transplant surveillance biopsies to evaluate and quantitate change in steatosis.
METHODS: All liver grafts with ≥ 10% steatosis were extracted for analysis. Allograft biopsies on day 0 and day 3 post-transplant were randomly read, in a blinded fashion, by a single, experienced liver pathologist. Ten non-steatotic grafts were interspersed as controls. Slides were scored for macro-, micro-, and total steatosis.
RESULTS: Overall, 151 subjects with steatosis were available for study. A decrease in steatosis was seen for most grafts: microvesicular (69%), macrovesicular (64%), and total steatosis (77%). There was a greater decrease in steatosis for grafts with high baseline steatosis (> 40% baseline steatosis with -30% reduction; 20%-39% baseline steatosis with -15% reduction; and < 20% baseline steatosis with -5% reduction).
CONCLUSIONS: These results confirm a marked post-transplant decrease in steatosis that occurs within 3 to 5 days for most liver grafts with steatosis. These findings support the continued use of liver grafts with steatosis as this pathology appears to resolve quickly after transplant.
METHODS: All liver grafts with ≥ 10% steatosis were extracted for analysis. Allograft biopsies on day 0 and day 3 post-transplant were randomly read, in a blinded fashion, by a single, experienced liver pathologist. Ten non-steatotic grafts were interspersed as controls. Slides were scored for macro-, micro-, and total steatosis.
RESULTS: Overall, 151 subjects with steatosis were available for study. A decrease in steatosis was seen for most grafts: microvesicular (69%), macrovesicular (64%), and total steatosis (77%). There was a greater decrease in steatosis for grafts with high baseline steatosis (> 40% baseline steatosis with -30% reduction; 20%-39% baseline steatosis with -15% reduction; and < 20% baseline steatosis with -5% reduction).
CONCLUSIONS: These results confirm a marked post-transplant decrease in steatosis that occurs within 3 to 5 days for most liver grafts with steatosis. These findings support the continued use of liver grafts with steatosis as this pathology appears to resolve quickly after transplant.