Journal of occupational and environmental medicine · 2021
The Association Between Dimethylacetamide Exposure and Liver Toxicity: A Large Retrospective Analysis in Workers From Four European Factories.
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Antoniou Evangelia E, Gelbke Heinz-Peter, Ballach Jochen, Zeegers Maurice P, Schrage Arnhild
Аннотация
OBJECTIVE: This study examines the association between 8-h time weighted N, N-dimethylacetamide (DMAc) air exposure and potential hepatocellular injury in a retrospective study among fibre-production workers in four European factories.
METHODS AND RESULTS: Twenty-nine (1.5%) of 1844 alanine aminotransferase (ALT) observations had liver values two times above normal; 0.2% three times above normal and 0.05% five times above normal. Two (0.1%) observations were indicative of hepatocellular injury. Logistic regression analyses showed an odds ratio for elevated ALT of 0.88 per 1 ppm (P trend = 0.39). Linear random effects regression analyses showed a decrease of one international unit (IU/L) ALT per 1 ppm increase of DMAc exposure (P = 0.002).
CONCLUSIONS: This study found no association between DMAc exposure and hepatoxicity amongst European workers. The prevalence of elevated liver values was lower compared to the general population without occupational exposure.
METHODS AND RESULTS: Twenty-nine (1.5%) of 1844 alanine aminotransferase (ALT) observations had liver values two times above normal; 0.2% three times above normal and 0.05% five times above normal. Two (0.1%) observations were indicative of hepatocellular injury. Logistic regression analyses showed an odds ratio for elevated ALT of 0.88 per 1 ppm (P trend = 0.39). Linear random effects regression analyses showed a decrease of one international unit (IU/L) ALT per 1 ppm increase of DMAc exposure (P = 0.002).
CONCLUSIONS: This study found no association between DMAc exposure and hepatoxicity amongst European workers. The prevalence of elevated liver values was lower compared to the general population without occupational exposure.