The European journal of surgery = Acta chirurgica · 1999
Expression of cholecystokinin-B/gastrin receptors in medullary thyroid cancer.
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Amiri-Mosavi A, Ahlman H, Tisell L E, Wängberg B, Kölby L, Forssell-Aronsson E, Lundberg P A, Lindstedt G, Nilsson O
Аннотация
OBJECTIVE: To characterise the cholecystokinin (CCK) receptor subtypes in medullary thyroid cancer by measuring the expression of CCK-A and CCK-B/gastrin receptor mRNA.
DESIGN: Open study.
SETTING: Teaching hospital, Sweden.
SUBJECTS: 6 patients with medullary thyroid cancer.
INTERVENTION: Pentagastrin stimulation test and measurement of calcitonin concentration. Biopsy specimens were analysed using reverse transcription polymerase chain reaction (RT-PCR).
MAIN OUTCOME MEASURE: Presence of CCK-A and CCK-B/gastrin receptors.
RESULTS: All 6 patients with medullary thyroid cancer had positive pentagastrin tests preoperatively. CCK-B/gastrin receptors but not CCK-A receptors were detected by RT-PCR in all six biopsy specimens. By contrast, no CCK receptors were found in normal thyroid tissues or in other thyroid tumours (follicular adenoma, papillary carcinoma, or anaplastic carcinoma).
CONCLUSION: The presence of CCK-B/gastrin receptors in medullary thyroid tumours may have important clinical implications.
DESIGN: Open study.
SETTING: Teaching hospital, Sweden.
SUBJECTS: 6 patients with medullary thyroid cancer.
INTERVENTION: Pentagastrin stimulation test and measurement of calcitonin concentration. Biopsy specimens were analysed using reverse transcription polymerase chain reaction (RT-PCR).
MAIN OUTCOME MEASURE: Presence of CCK-A and CCK-B/gastrin receptors.
RESULTS: All 6 patients with medullary thyroid cancer had positive pentagastrin tests preoperatively. CCK-B/gastrin receptors but not CCK-A receptors were detected by RT-PCR in all six biopsy specimens. By contrast, no CCK receptors were found in normal thyroid tissues or in other thyroid tumours (follicular adenoma, papillary carcinoma, or anaplastic carcinoma).
CONCLUSION: The presence of CCK-B/gastrin receptors in medullary thyroid tumours may have important clinical implications.