European journal of radiology · 2017
Value of diffusion tensor imaging in differentiating malignant from benign parotid gland tumors.
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Takumi Koji, Fukukura Yoshihiko, Hakamada Hiroto, Ideue Junichi, Kumagae Yuichi, Yoshiura Takashi
Аннотация
PURPOSE: To evaluate whether diffusion tensor imaging (DTI) can be used to differentiate malignant parotid gland tumors from the benign ones.
MATERIALS AND METHODS: The study population comprised 59 parotid gland tumors (24 Warthin's tumors, 19 pleomorphic adenomas, seven other benign tumors, and nine malignant tumors). Single-shot echo-planar DTI was performed with motion-probing gradients along 30 noncollinear directions (b=1000s/mm2) at 3.0T. Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values for benign and malignant tumors were compared using the Mann-Whitney U test. Receiver-operating characteristic (ROC) curve analysis was performed to assess the ability of the ADC and FA values to differentiate malignant tumors from the benign ones.
RESULTS: ADC values showed no significant difference between malignant (0.93±0.21×10-3mm2/s) and benign tumors (1.19±0.50×10-3mm2/s) (p=0.225). FA values of malignant tumors were significantly higher than those of benign tumors (0.26±0.06 vs. 0.17±0.05, p<0.001). The area under the ROC curve of FA was significantly greater than that under the curve of ADC (0.884 vs. 0.628, p=0.010).
CONCLUSIONS: DTI, particularly FA, can help differentiate malignant parotid gland tumors from the benign ones.
MATERIALS AND METHODS: The study population comprised 59 parotid gland tumors (24 Warthin's tumors, 19 pleomorphic adenomas, seven other benign tumors, and nine malignant tumors). Single-shot echo-planar DTI was performed with motion-probing gradients along 30 noncollinear directions (b=1000s/mm2) at 3.0T. Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values for benign and malignant tumors were compared using the Mann-Whitney U test. Receiver-operating characteristic (ROC) curve analysis was performed to assess the ability of the ADC and FA values to differentiate malignant tumors from the benign ones.
RESULTS: ADC values showed no significant difference between malignant (0.93±0.21×10-3mm2/s) and benign tumors (1.19±0.50×10-3mm2/s) (p=0.225). FA values of malignant tumors were significantly higher than those of benign tumors (0.26±0.06 vs. 0.17±0.05, p<0.001). The area under the ROC curve of FA was significantly greater than that under the curve of ADC (0.884 vs. 0.628, p=0.010).
CONCLUSIONS: DTI, particularly FA, can help differentiate malignant parotid gland tumors from the benign ones.