Scientific reports · 2023
Epithelial cell-derived cytokine TSLP activates regulatory T cells by enhancing fatty acid uptake.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Kasuya Tadamichi, Tanaka Shigeru, Tamura Jun, Etori Keishi, Shoda Jumpei, Hattori Koto, Endo Yusuke, Kitajima Masayuki, Kageyama Takahiro, Iwamoto Taro, Yokota Masaya, Iwata Arifumi, Suto Akira, Suzuki Kotaro, Suzuki Harumi, Ziegler Steven F, Nakajima Hiroshi
Аннотация
Epithelial cells control a variety of immune cells by secreting cytokines to maintain tissue homeostasis on mucosal surfaces. Regulatory T (Treg) cells are essential for immune homeostasis and for preventing tissue inflammation; however, the precise molecular mechanisms by which epithelial cell-derived cytokines function on Treg cells in the epithelial tissues are not well understood. Here, we show that peripheral Treg cells preferentially respond to thymic stromal lymphoprotein (TSLP). Although TSLP does not affect thymic Treg differentiation, TSLP receptor-deficient induced Treg cells derived from naïve CD4+ T cells are less activated in an adoptive transfer model of colitis. Mechanistically, TSLP activates induced Treg cells partially through mTORC1 activation and fatty acid uptake. Thus, TSLP modulates the activation status of induced Treg through the enhanced uptake of fatty acids to maintain homeostasis in the large intestine.