Fertility and sterility · 2021
Evaluating efficacy of intravenous carbetocin in reducing blood loss during abdominal myomectomy: a randomized controlled trial.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Taher Ayman, Farouk Dalia, Mohamed Kotb Mohamed Mahmoud, Ghamry Nevein Kamal, Kholaif Khaled, A Mageed A Allah Ahmed, Ali Ahmed Said, Osman Omneya M, Nabil Hala, Islam Yomna, Bakry Mohamed Sobhy, Islam Bassem Aly, Alalfy Mahmoud, Nassar Salma Ashraf, Bosilah Almandouh H, Ghanem Ashraf A, Ali Rund Nansy Mohamed, Refaat Rania, Abdel Wahed Ali Hamada Ashry, Bakry Ahmed, Ashour Ahmed S A, Nabil Mohamed, Zaki Sherif Sameh
Аннотация
OBJECTIVE: To evaluate the efficacy of carbetocin versus placebo in decreasing intraoperative blood loss and the need for blood transfusion during abdominal myomectomy.
DESIGN: Randomized, double-blind, placebo-controlled trial.
SETTING: Tertiary university hospital from September 2019 to February 2020.
PATIENT(S): A total of 138 women with symptomatic leiomyoma who were candidates for abdominal myomectomy (n = 69 in each group).
INTERVENTION(S): We randomized the study participants in a 1:1 ratio to carbetocin and placebo groups. Intravenous 100 μg carbetocin or placebo was administered slowly after induction of anesthesia.
MAIN OUTCOME MEASURE(S): Intraoperative blood loss, need for blood transfusion, postoperative hemoglobin, operative time, length of hospitalization, and drug side-effects.
RESULT(S): The baseline characteristics were similar among all groups. Carbetocin had significantly lower intraoperative blood loss compared with placebo (mean difference 184 mL). Hemoglobin level 24 hours after surgery was significantly lower in the placebo group than in the carbetocin group (9.1 ± 0.8 vs. 10.3 ± 0.6 g/dL). Eight women in the carbetocin group needed blood transfusion compared with 17 in placebo group. Operative time, length of hospitalization, and side-effects were similar in both groups.
CONCLUSION(S): A single preoperative intravenous dose of 100 μg carbetocin is a simple, practical, and effective method of decreasing intraoperative blood loss and the need for blood transfusion during abdominal myomectomy, with tolerable, few, nonsignificant side-effects.
CLINICAL TRIAL REGISTRATION NUMBER: NCT04083625.
DESIGN: Randomized, double-blind, placebo-controlled trial.
SETTING: Tertiary university hospital from September 2019 to February 2020.
PATIENT(S): A total of 138 women with symptomatic leiomyoma who were candidates for abdominal myomectomy (n = 69 in each group).
INTERVENTION(S): We randomized the study participants in a 1:1 ratio to carbetocin and placebo groups. Intravenous 100 μg carbetocin or placebo was administered slowly after induction of anesthesia.
MAIN OUTCOME MEASURE(S): Intraoperative blood loss, need for blood transfusion, postoperative hemoglobin, operative time, length of hospitalization, and drug side-effects.
RESULT(S): The baseline characteristics were similar among all groups. Carbetocin had significantly lower intraoperative blood loss compared with placebo (mean difference 184 mL). Hemoglobin level 24 hours after surgery was significantly lower in the placebo group than in the carbetocin group (9.1 ± 0.8 vs. 10.3 ± 0.6 g/dL). Eight women in the carbetocin group needed blood transfusion compared with 17 in placebo group. Operative time, length of hospitalization, and side-effects were similar in both groups.
CONCLUSION(S): A single preoperative intravenous dose of 100 μg carbetocin is a simple, practical, and effective method of decreasing intraoperative blood loss and the need for blood transfusion during abdominal myomectomy, with tolerable, few, nonsignificant side-effects.
CLINICAL TRIAL REGISTRATION NUMBER: NCT04083625.