Radiation protection dosimetry · 2024
Effects of low-dose rate radiation on immune and epigenetic regulation of the mouse testes.
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Uemura Ippei, Takahashi-Suzuki Natsuko, Kuroda Saki, Kumagai Kaede, Tsutsumi Yuki, Anderson Donovan, Satoh Takashi, Yamashiro Hideaki, Miura Tomisato, Yamauchi Kazumi, Nakata Akifumi
Аннотация
This study investigated the effects of chronic low-dose-rate radiation exposure on gene expression related to immunological defense mechanisms and epigenetic regulation in the testis of male mice. The study found that radiation exposure (4.5 mGy/hr until 4000 mGy) led to a significant decrease in the expression of genes involved in epigenetic regulation and a significant increase in the expression of several genes linked to innate and acquired immunity, suggesting a noticeable effect on the immune response. In addition, there was a significant increase in the expression of SRY-box transcription factor 9, which plays a crucial role in testicular development, indicating a response to irradiation. These findings provide insights into the biological effects of chronic low-dose-rate radiation exposure on innate immunity and epigenetic regulation in the testis.