The British journal of ophthalmology · 2025
Intracellular dark spots are associated with endothelial cell loss after Descemet's stripping automated endothelial keratoplasty.
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Mori-Ogiwara Yurina, Yagi-Yaguchi Yukari, Ibrahim Osama, Higa Kazunari, Kasamatsu Hirotsugu, Kanda Takahiro, Tomida Daisuke, Oie Yoshinori, Hayashi Takahiko, Shimazaki Jun, Yamaguchi Takefumi
Аннотация
Intracellular dark endothelial spots (IDESs) on specular microscopy developed in 78/122 patients (63.9%) after Descemet stripping automated endothelial keratoplasty (DSAEK). Endothelial cell density (ECD) after DSAEK was significantly smaller in eyes with IDES when compared with those without at all time points (p<0.001) despite no significant difference in graft ECD (p=0.43), resulting in an increased rate of endothelial failure (p=0.044). The presence of glaucoma (OR=2.22, p=0.027), iris damage (OR=2.85, p=0.004) and non-Fuchs status (OR=2.37, p=0.018) were identified as risk factors for IDES development. Preoperative total protein level in aqueous humour was significantly higher in eye with endothelial failure than those without (p=0.0057).