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Revista do Instituto de Medicina Tropical de Sao Paulo · 2025

Serology survey of chikungunya virus in high-risk pregnant women and placental tissue findings.

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Fajardo Thamirys Cosmo Grillo, Quadros Junior Antonio Carlos de, Pinto Clóvis Antonio Lopes, Santos Geovane Ribeiro Dos, Silva Andrea Cristina Botelho da, Catalan Daniel Thome, Bertozzi Ana Paula Antunes Pascalicchio, Gazeta Rosa Estela, Moron Antonio Fernandes, Passos Saulo Duarte, Jundiai Zika Cohort Group, Mello Alexandra Siqueira, Soriano-Arandes Antoni, Alarcon Ana, Garcia-Alix Alfredo, Silva Alify Bertoldo da, Ventura Dora Fix, Oliveira Danielle Bruna Leal de, Tambalo Danilla Soares, Lima Diego da Silva, Fujiwara Dirce Takako, Durigon Edison Luiz, Bagne Eduardo Roberto, Velasco Fernanda Guerra, Baran Luiz Claudio Portnoi, Arita Fernando Novo, Hernandez Francisco Del Moral, Almeida Juliana Paula Gomes de, Camandulli Karen Richter, Castro Lucas Pires de, Machado Márcia Borges, Zatz Mayana, Rodrigues Maria Manoela Duarte, Rizzo Maria de Fátima Valente, Farrão Maria Amélia, Leite Mirella Nayane Barbosa, Florence Filho Nemésio, Loiola Patrícia Carvalho, Prestes Raquel, Dezena Rita de Cássia Aguirre, Bonon Sandra Helena Alves, Vranjac Sergio, Rosemberg Sérgio, Sarmento Stephanno Gomes Pereira, Witkinchi Steven Sol, Souza Tathiana Ghisi de, Pandini Viviane Cristina Martori, Paiva Viviam Paschoarelli

Аннотация

Evidence suggests a risk of maternal transmission of chikungunya virus (CHIKV) during the first and third trimesters, potentially leading to miscarriage or neurological consequences for the fetus. This study aimed to conduct a serological survey for CHIKV among women with high-risk pregnancies and analyze neonatal variables and placental tissue alterations. From March 2016 to April 2021, serological, histological, and molecular tests for CHIKV were performed. Blood samples were analyzed for anti-CHIKV IgG and IgM antibodies, and placental tissue was examined for CHIKV RNA and histological changes. Among pregnant patients, 1.33% (7/526) had reactive IgG, and 0.38% (2/526) had IgM/IgG-type antibodies during delivery. Although placental histology of CHIKV disease showed alterations, no viral genetic material was identified in the analyzed tissues. Therefore, further research is needed, including the use of complementary diagnostic techniques, to better understand the impact of this relatively new disease among high-risk pregnant women and newborns.

Предметные рубрики MeSH

ИП Урсолов Владлен Сергеевич

ИНН 500118482352 · ОГРНИП 314500117700049

Реквизиты и контакты