Journal of clinical anesthesia · 2025
Hemidiaphragmatic paralysis after ultrasound-guided brachial plexus blocks for shoulder surgery: A systematic review and meta-analysis of randomized clinical trials.
СтатьяМетаанализСистематический обзорПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Oliver-Fornies P, Aragon-Benedi C, Gomez Gomez R, Anton Rodriguez Cristina, San-Jose-Montano Blanca, Yamak Altinpulluk Ece, Fajardo Perez M
Аннотация
STUDY OBJECTIVE: This review aimed to explore whether diaphragm-sparing regional techniques are more effective at preventing hemidiaphragm paralysis than conventional interscalene brachial plexus blockade (ISB) following shoulder surgery.
DESIGN: Systematic review of randomized clinical trials (RCTs) including meta-analyses, meta-regression, trial sequential analyses (TSA) and GRADE methodology.
SETTING: Online databases (Cochrane Library; MEDLINE; EMBASE; Scopus; Web of Science; and international trial registries) were searched for RCTs up to December 2022.
PATIENTS: Adult patients undergoing shoulder surgery following ultrasound-guided brachial plexus blockade, where incidence of hemidiaphragmatic paralysis was reported.
INTERVENTIONS: Diaphragm-sparing techniques following ultrasound-guided brachial plexus blockade were included: modifications of ISB (low-volume, extrafascial, and lower concentration); superior trunk block; supraclavicular brachial plexus block, infraclavicular brachial plexus block; costoclavicular brachial plexus block; and anterior and posterior approaches to the suprascapular nerve block.
MEASUREMENTS: The primary endpoint was the incidence of complete hemidiaphragmatic paralysis. Secondary endpoints included postoperative analgesia and safety-related outcomes.
MAIN RESULTS: Twenty-eight RCTs involving 1737 subjects were identified. Of these, 22 were eligible for meta-analysis. Six regional techniques were analysed. The low-volume technique significantly reduced the incidence of hemidiaphragmatic paralysis as compared with the conventional ISB (risk ratio 0.62; 95 % CI 0.42 to 0.91; p = 0.02; absolute risk difference - 0.30 [95 % CI -0.39 to -0.20]; I2 = 80 %) at short-term follow-up. TSA confirmed the results of this meta-analysis but did not reach the required sample size by 19.5 %, indicating that the result was not definitive. The combined infraclavicular-suprascapular blocks, the extrafascial technique, the lower concentration technique, and the supraclavicular block reduced the incidence of hemidiaphragmatic paralysis by 97 %, 64 %, 57 % and 46 %, respectively. For the superior trunk block, TSA did not reach statistical significance.
CONCLUSIONS: There is conclusive evidence that the extrafascial technique (high-level); lower concentration technique (moderate-level); and the supraclavicular blockade (low-level) are less detrimental to hemidiaphragmatic paralysis than the conventional ISB. However, the results for other comparisons were not definitive. Systematic review protocol: PROSPERO CRD42022335056.
DESIGN: Systematic review of randomized clinical trials (RCTs) including meta-analyses, meta-regression, trial sequential analyses (TSA) and GRADE methodology.
SETTING: Online databases (Cochrane Library; MEDLINE; EMBASE; Scopus; Web of Science; and international trial registries) were searched for RCTs up to December 2022.
PATIENTS: Adult patients undergoing shoulder surgery following ultrasound-guided brachial plexus blockade, where incidence of hemidiaphragmatic paralysis was reported.
INTERVENTIONS: Diaphragm-sparing techniques following ultrasound-guided brachial plexus blockade were included: modifications of ISB (low-volume, extrafascial, and lower concentration); superior trunk block; supraclavicular brachial plexus block, infraclavicular brachial plexus block; costoclavicular brachial plexus block; and anterior and posterior approaches to the suprascapular nerve block.
MEASUREMENTS: The primary endpoint was the incidence of complete hemidiaphragmatic paralysis. Secondary endpoints included postoperative analgesia and safety-related outcomes.
MAIN RESULTS: Twenty-eight RCTs involving 1737 subjects were identified. Of these, 22 were eligible for meta-analysis. Six regional techniques were analysed. The low-volume technique significantly reduced the incidence of hemidiaphragmatic paralysis as compared with the conventional ISB (risk ratio 0.62; 95 % CI 0.42 to 0.91; p = 0.02; absolute risk difference - 0.30 [95 % CI -0.39 to -0.20]; I2 = 80 %) at short-term follow-up. TSA confirmed the results of this meta-analysis but did not reach the required sample size by 19.5 %, indicating that the result was not definitive. The combined infraclavicular-suprascapular blocks, the extrafascial technique, the lower concentration technique, and the supraclavicular block reduced the incidence of hemidiaphragmatic paralysis by 97 %, 64 %, 57 % and 46 %, respectively. For the superior trunk block, TSA did not reach statistical significance.
CONCLUSIONS: There is conclusive evidence that the extrafascial technique (high-level); lower concentration technique (moderate-level); and the supraclavicular blockade (low-level) are less detrimental to hemidiaphragmatic paralysis than the conventional ISB. However, the results for other comparisons were not definitive. Systematic review protocol: PROSPERO CRD42022335056.