Archives of oral biology · 2010
Calcitonin gene-related peptide- and adrenomedullin-induced facilitation of calcium current in submandibular ganglion.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Endoh Takayuki, Shibukawa Yoshiyuki, Tsumura Maki, Ichikawa Hideki, Tazaki Masakazu, Inoue Takashi
Аннотация
OBJECTIVE: The control of saliva secretion is mainly under parasympathetic control. The submandibular ganglion (SMG) is a parasympathetic ganglion which receives inputs from preganglionic cholinergic neurons, and innervates the submandibular salivary gland to control saliva secretion. The aim of this study was to investigate if adrenomedullin (ADM) and/or calcitonin gene-related peptide (CGRP) modulate voltage-dependent calcium channel (VDCCs) current (I(Ca)) in SMG.
DESIGN: The profile of CGRP and ADM actions in SMG was studied using the whole-cell configuration of the patch-clamp technique.
RESULTS: Both ADM and CGRP facilitated I(Ca). These facilitations were attenuated by intracellular dialysis of the anti-Gα(s)-protein and pretreatment of SQ22536 (an adenylate cyclase inhibitor).
CONCLUSIONS: ADM and CGRP facilitates VDCCs mediated by Gα(s)-protein and adenylate cyclase in SMG.
DESIGN: The profile of CGRP and ADM actions in SMG was studied using the whole-cell configuration of the patch-clamp technique.
RESULTS: Both ADM and CGRP facilitated I(Ca). These facilitations were attenuated by intracellular dialysis of the anti-Gα(s)-protein and pretreatment of SQ22536 (an adenylate cyclase inhibitor).
CONCLUSIONS: ADM and CGRP facilitates VDCCs mediated by Gα(s)-protein and adenylate cyclase in SMG.