Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology · 2015
[GASTROESOPHAGEAL REFLUXED DISEASE IN PERSONS WITH OBESITY AND LEPTIN RESISTANCE].
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Livzan M A, Lapteva I V, Krolevets T S
Аннотация
UNLABELLED: AIM OR OBJECTIVE: to examine the levels of leptin and its soluble receptor in the serum of patients with gastroesophageal refluxed disease (GERD) with different weight.
METHODS: We examined 125 patients with GERD. We asked patients, assessed an anthropometric indices, did a biochemical analysis of blood, ultrasonic studies of abdominal, endoscope examination of the esophagus and stomach, pH monitoring, assessed levels leptin and its soluble receptor. We separated patients in two groups: the main group (n = 105) - patients with overweight and obesity, the comparison group (n = 20) - with normal weight.
RESULTS: Values of waist circumference, the hips, its relationship, level of glucose and triglycerides was higher in main group (p<0, (10) (10)3, p<0,00002, p<0,0096, p<0,02, p<0,008, respectively). Leptin levels in patients with obesity and overweight was significantly higher and the level of its receptors was significantly lower (mediana of leptin levels 29,81 (12,63-45,62) in main group versus 4,13 (3,03-5,79), mediana of leptin's receptors 18,74 (14,98-25,11) versus 31,82 (27,81-34,43), respectively). Between these indicators in main group was revealed negative correlation of moderate strength (rs= (-0,452), p<0,0004). In group with overweight and obesity a fairly significant correlation between the level of adipokines and severity of symptoms of GERD were found: negative correlation of moderate intensity between leptin and severity of dysphagia (rs= (-0,259), p<0,05) and positive correlation of moderate intensity between leptin's receptor and severity of belching (rs= (-0,295), p<0,02). As well as a fairly significant positive association of moderate strength between leptin levels and the maximum value of pH in the stomach (rs= (-0,499), p<0,03) and between leptin's receptor and index relationship of pH in the cardia of the stomach to the body (rs= (-0,505), p<0,04) were found.
CONCLUSIONS: leptinresistance in individuals with overweight and obesity is associated with features of GERD.
METHODS: We examined 125 patients with GERD. We asked patients, assessed an anthropometric indices, did a biochemical analysis of blood, ultrasonic studies of abdominal, endoscope examination of the esophagus and stomach, pH monitoring, assessed levels leptin and its soluble receptor. We separated patients in two groups: the main group (n = 105) - patients with overweight and obesity, the comparison group (n = 20) - with normal weight.
RESULTS: Values of waist circumference, the hips, its relationship, level of glucose and triglycerides was higher in main group (p<0, (10) (10)3, p<0,00002, p<0,0096, p<0,02, p<0,008, respectively). Leptin levels in patients with obesity and overweight was significantly higher and the level of its receptors was significantly lower (mediana of leptin levels 29,81 (12,63-45,62) in main group versus 4,13 (3,03-5,79), mediana of leptin's receptors 18,74 (14,98-25,11) versus 31,82 (27,81-34,43), respectively). Between these indicators in main group was revealed negative correlation of moderate strength (rs= (-0,452), p<0,0004). In group with overweight and obesity a fairly significant correlation between the level of adipokines and severity of symptoms of GERD were found: negative correlation of moderate intensity between leptin and severity of dysphagia (rs= (-0,259), p<0,05) and positive correlation of moderate intensity between leptin's receptor and severity of belching (rs= (-0,295), p<0,02). As well as a fairly significant positive association of moderate strength between leptin levels and the maximum value of pH in the stomach (rs= (-0,499), p<0,03) and between leptin's receptor and index relationship of pH in the cardia of the stomach to the body (rs= (-0,505), p<0,04) were found.
CONCLUSIONS: leptinresistance in individuals with overweight and obesity is associated with features of GERD.