[GASTROESOPHAGEAL REFLUXED DISEASE IN PERSONS WITH OBESITY AND LEPTIN RESISTANCE].

UNLABELLED: AIM OR

OBJECTIVE

to examine the levels of leptin and its soluble receptor in the serum of patients with gastroesophageal refluxed disease (GERD) with different weight.

METHODS

We examined 125 patients with GERD. We asked patients, assessed an anthropometric indices, did a biochemical analysis of blood, ultrasonic studies of abdominal, endoscope examination of the esophagus and stomach, pH monitoring, assessed levels leptin and its soluble receptor. We separated patients in two groups: the main group (n = 105) - patients with overweight and obesity, the comparison group (n = 20) - with normal weight.

RESULTS

Values of waist circumference, the hips, its relationship, level of glucose and triglycerides was higher in main group (p<0, (10) (10)3, p<0,00002, p<0,0096, p<0,02, p<0,008, respectively). Leptin levels in patients with obesity and overweight was significantly higher and the level of its receptors was significantly lower (mediana of leptin levels 29,81 (12,63-45,62) in main group versus 4,13 (3,03-5,79), mediana of leptin's receptors 18,74 (14,98-25,11) versus 31,82 (27,81-34,43), respectively). Between these indicators in main group was revealed negative correlation of moderate strength (rs= (-0,452), p<0,0004). In group with overweight and obesity a fairly significant correlation between the level of adipokines and severity of symptoms of GERD were found: negative correlation of moderate intensity between leptin and severity of dysphagia (rs= (-0,259), p<0,05) and positive correlation of moderate intensity between leptin's receptor and severity of belching (rs= (-0,295), p<0,02). As well as a fairly significant positive association of moderate strength between leptin levels and the maximum value of pH in the stomach (rs= (-0,499), p<0,03) and between leptin's receptor and index relationship of pH in the cardia of the stomach to the body (rs= (-0,505), p<0,04) were found.

CONCLUSIONS

leptinresistance in individuals with overweight and obesity is associated with features of GERD.