Somatostatin-28-like immunoreactivity in the stomach.

Localization of somatostatin-28 and somatostatin-14 immunoreactive cells in the human, canine and cat's stomach was studied by an indirect immunoperoxidase method using somatostatin-14 antisera and specific antisera against somatostatin-28. The somatostatin-28 immunoreactive cells belonged to the endocrine-like cells of the fundic glands and pyloric antrum of the human, canine and cat's stomach. These cells were identical to somatostatin-14 ones. Since immunocytochemical cross-reaction between specific antisera against somatostatin-28 and somatostatin-14 was not found, it was suggested that the coexistence of N-terminal amino acid sequence of somatostatin-28 and somatostatin-14 in one and the same cell seemed to be most likely. Thus, it seems probable that somatostatin-28 originally isolated from porcine and ovine tissues may be constantly present in other mammals.