[Modulation of rat myometrium contractile activity by peptidoglycan of Staphylococcus aureus cell wall].

Peptidoglycan of Staphylococcus aureus cell wall impact on the both estrogen-treated and pseudopragnant rat myometrium contractile activity dynamics was studied. The results of experiments shown that rat myomatrium sensitivity to peptidoglican depends on the hormonal background. Peptidoglycan modified the myometrium contractile activity of both estrogen-treated and pseudopragnant rats. In estrogen-treated rat myometrium peptidoglycan reduces frequency and duration of contractions (elongated the uterine cycle) while in the pseudopregnant rat myometrium it increased the amplitude as well as the duration and the freqwency (deshortened the uterine cycle). During the experiments we found that peptidoglycan has stronger uterotonic effect than prostaglandin F2α. In this connection we conclude that the changes ofmyometral contractile activity after peptidoglycan action may have negative effects for fertility and course of pregnancy.