International journal of obstetric anesthesia · 2014
5-HT3 receptor antagonists do not alter spontaneous contraction of pregnant myometrium in vitro.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Lin Xuemei, Du Yu, Tang Yuying, Zeng Kui, Ni Juan, Liu Jin, Zhou Jie
Аннотация
BACKGROUND: 5-HT3 receptor antagonists are effective antiemetics for perioperative use. However, their effects on myometrial contractility remain unknown. We examined whether three different 5-HT3 receptor antagonists could affect the contraction of human myometrium.
METHODS: Samples of human myometrium were taken from parturients undergoing elective cesarean delivery. Effects of ondansetron, granisetron and tropisetron (over a range of 1-10(4)ng/mL) on spontaneous contraction (ratios of amplitude, interval, and duration of the contraction) were examined and compared to saline controls (n=6 for each agent).
RESULTS: None of the three 5-HT3 receptor antagonists significantly affected myometrial contraction.
CONCLUSION: 5-HT3 receptor antagonists do not affect the contraction of myometrial strips isolated from term pregnant women.
METHODS: Samples of human myometrium were taken from parturients undergoing elective cesarean delivery. Effects of ondansetron, granisetron and tropisetron (over a range of 1-10(4)ng/mL) on spontaneous contraction (ratios of amplitude, interval, and duration of the contraction) were examined and compared to saline controls (n=6 for each agent).
RESULTS: None of the three 5-HT3 receptor antagonists significantly affected myometrial contraction.
CONCLUSION: 5-HT3 receptor antagonists do not affect the contraction of myometrial strips isolated from term pregnant women.