Медицинская библиотека · Science (New York, N.Y.) · 2024

Cross-species single-cell spatial transcriptomic atlases of the cerebellar cortex.

Hao Shijie, Zhu Xiaojia, Huang Zhi, Yang Qianqian, Liu Hean, Wu Yan, Zhan Yafeng, Dong Yu, Li Chao, Wang He, Haasdijk Elize, Wu Zihan, Li Shenglong, Yan Haotian, Zhu Lijing, Guo Shiyong, Wang Zefang, Ye Aojun, Lin Youning, Cui Luman, Tan Xing, Liu Huanlin, Wang Mingli, Chen Jing, Zhong Yanqing, Du Wensi, Wang Guangling, Lai Tingting, Cao Mengdi, Yang Tao, Xu Yuanfang, Li Ling, Yu Qian, Zhuang Zhenkun, Xia Ying, Lei Ying, An Yingjie, Cheng Mengnan, Zhao Yun, Han Lei, Yuan Yue, Song Xinxiang, Song Yumo, Gu Liqin, Liu Chang, Lin Xiumei, Wang Ruiqi, Wang Zhifeng, Wang Yang, Li Shenyu, Li Huanhuan, Song Jingjing, Chen Mengni, Zhou Wanqiu, Yuan Nini, Sun Suhong, Wang Shiwen, Chen Yu, Zheng Mingyuan, Fang Jiao, Zhang Ruiyi, Zhang Shuzhen, Chai Qinwen, Liu Jiabing, Wei Wu, He Jie, Zhou Haibo, Sun Yangang, Liu Zhen, Liu Chuanyu, Yao Jianhua, Liang Zhifeng, Xu Xun, Poo Muming, Li Chengyu, De Zeeuw Chris I, Shen Zhiming, Liu Zhiyong, Liu Longqi, Liu Shiping, Sun Yidi, Liu Cirong

СтатьяСравнительное исследованиеПоддержка исследования: вне правительства СШАПеревод пока не подготовлен

Аннотация

The molecular and cellular organization of the primate cerebellum remains poorly characterized. We obtained single-cell spatial transcriptomic atlases of macaque, marmoset, and mouse cerebella and identified primate-specific cell subtypes, including Purkinje cells and molecular-layer interneurons, that show different expression of the glutamate ionotropic receptor Delta type subunit 2 (GRID2) gene. Distinct gene expression profiles were found in anterior, posterior, and vestibular regions in all species, whereas region-selective gene expression was predominantly observed in the granular layer of primates and in the Purkinje layer of mice. Gene expression gradients in the cerebellar cortex matched well with functional connectivity gradients revealed with awake functional magnetic resonance imaging, with more lobule-specific differences between primates and mice than between two primate species. These comprehensive atlases and comparative analyses provide the basis for understanding cerebellar evolution and function.

Для цитирования: Hao Shijie, Zhu Xiaojia, Huang Zhi, Yang Qianqian, Liu Hean, Wu Yan, Zhan Yafeng, Dong Yu, Li Chao, Wang He, Haasdijk Elize, Wu Zihan, Li Shenglong, Yan Haotian, Zhu Lijing, Guo Shiyong, Wang Zefang, Ye Aojun, Lin Youning, Cui Luman, Tan Xing, Liu Huanlin, Wang Mingli, Chen Jing, Zhong Yanqing, Du Wensi, Wang Guangling, Lai Tingting, Cao Mengdi, Yang Tao, Xu Yuanfang, Li Ling, Yu Qian, Zhuang Zhenkun, Xia Ying, Lei Ying, An Yingjie, Cheng Mengnan, Zhao Yun, Han Lei, Yuan Yue, Song Xinxiang, Song Yumo, Gu Liqin, Liu Chang, Lin Xiumei, Wang Ruiqi, Wang Zhifeng, Wang Yang, Li Shenyu, Li Huanhuan, Song Jingjing, Chen Mengni, Zhou Wanqiu, Yuan Nini, Sun Suhong, Wang Shiwen, Chen Yu, Zheng Mingyuan, Fang Jiao, Zhang Ruiyi, Zhang Shuzhen, Chai Qinwen, Liu Jiabing, Wei Wu, He Jie, Zhou Haibo, Sun Yangang, Liu Zhen, Liu Chuanyu, Yao Jianhua, Liang Zhifeng, Xu Xun, Poo Muming, Li Chengyu, De Zeeuw Chris I, Shen Zhiming, Liu Zhiyong, Liu Longqi, Liu Shiping, Sun Yidi, Liu Cirong. Cross-species single-cell spatial transcriptomic atlases of the cerebellar cortex.. Science (New York, N.Y.). 2024. DOI: 10.1126/science.ado3927.

Предметные рубрики MeSH

Animals Male Mice Atlases as Topic Callithrix Cerebellar Cortex Interneurons Macaca Magnetic Resonance Imaging Purkinje Cells Receptors, Glutamate Receptors, Ionotropic Glutamate Single-Cell Analysis Species Specificity Transcriptome Connectome

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