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Войти в исследования Journal of affective disorders · 2026
Alexithymia mediates white-matter microstructure and substance use escalation in trauma-exposed individuals.
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Luster Charlotte B, Morie Kristen P, Legido Jenny, Mayes Linda C, Potenza Marc N, Zhai Zu Wei
Аннотация
INTRODUCTION: Alexithymia has been separately associated with differences in white-matter and with substance use (SU). Childhood trauma has also been associated with white-matter differences, alexithymia, and SU. This study explored the moderating effect of childhood trauma on the indirect effect of white-matter microstructure on SU escalation through alexithymia.
METHODS: Participants were 44 young adults from a larger longitudinal cohort, and data on childhood trauma, alexithymia, white-matter were acquired initially. SU escalation was calculated from the quantity and frequency of SU initially and two-years later. Diffusion-weighted white-matter data were used to calculate tensor-derived and crossing-fiber anisotropy measures. Multivariable analyses and moderated mediation models tested whether the indirect relationship between corpus callosum anisotropy and SU escalation through alexithymia differed between levels of childhood trauma.
RESULTS: Splenium primary-fiber anisotropy correlated with lower SU escalation whereas splenium secondary-fiber anisotropy correlated with greater SU escalation and alexithymic difficulty describing feelings. Within moderated mediation models, childhood trauma levels moderated associations between splenium primary-fiber anisotropy and difficulty describing feelings. Conditional effects showed that at greater childhood trauma, lower splenium primary-fiber anisotropy associated with greater difficulty describing feeling, and difficulty describing feelings mediated associations between splenium primary-fiber anisotropy and SU escalation.
CONCLUSIONS: Trauma may moderate maladaptive emotion-language processing in individuals with specific white-matter differences, and alexithymia may be directly or indirectly associated with SU escalation. Individuals with early-life trauma and splenium white-matter differences may represent a vulnerable population, which may be an important focus from interventions that bolster stress management and emotion regulation.
METHODS: Participants were 44 young adults from a larger longitudinal cohort, and data on childhood trauma, alexithymia, white-matter were acquired initially. SU escalation was calculated from the quantity and frequency of SU initially and two-years later. Diffusion-weighted white-matter data were used to calculate tensor-derived and crossing-fiber anisotropy measures. Multivariable analyses and moderated mediation models tested whether the indirect relationship between corpus callosum anisotropy and SU escalation through alexithymia differed between levels of childhood trauma.
RESULTS: Splenium primary-fiber anisotropy correlated with lower SU escalation whereas splenium secondary-fiber anisotropy correlated with greater SU escalation and alexithymic difficulty describing feelings. Within moderated mediation models, childhood trauma levels moderated associations between splenium primary-fiber anisotropy and difficulty describing feelings. Conditional effects showed that at greater childhood trauma, lower splenium primary-fiber anisotropy associated with greater difficulty describing feeling, and difficulty describing feelings mediated associations between splenium primary-fiber anisotropy and SU escalation.
CONCLUSIONS: Trauma may moderate maladaptive emotion-language processing in individuals with specific white-matter differences, and alexithymia may be directly or indirectly associated with SU escalation. Individuals with early-life trauma and splenium white-matter differences may represent a vulnerable population, which may be an important focus from interventions that bolster stress management and emotion regulation.