Медицинская библиотека · Anticancer research · 2007

Ascorbic acid induces apoptosis in adult T-cell leukemia.

Harakeh Steve, Diab-Assaf Mona, Khalife Jihane C, Abu-el-Ardat Khalil A, Baydoun Elias, Niedzwiecki Aleksandra, El-Sabban Marwan E, Rath Mathias

СтатьяПоддержка исследования: вне правительства СШАПеревод пока не подготовлен

Аннотация

BACKGROUND

Adult T-cell leukemia (ATL) is an acute malignancy of activated T-cells caused by the human T-cell lymphotrophic virus type-1 (HTLV-1).

MATERIALS AND

METHODS

The effects of non-cytotoxic concentrations of ascorbic acid (AA) were evaluated against HTLV-1 positive and negative cells. The effect of AA on apoptosis and proliferation was evaluated by cell cycle analysis. The role of p53, p21 Bax and Bcl-2a on cell cycle modulation and apoptosis was also assessed. The anti-proliferative effects were tested by determining the changes in the expression of transforming growth factors (TGF-alpha, TGF-beta1 and TGF-beta2).

RESULTS

Ascorbic acid was found to reduce the proliferation of cells and induce apoptosis by the modulation of p53, p21, Bcl-2 and Bax.

CONCLUSION

The results of this study show the anti-proliferative effects of AA against leukemic cells.

Для цитирования: Harakeh Steve, Diab-Assaf Mona, Khalife Jihane C, Abu-el-Ardat Khalil A, Baydoun Elias, Niedzwiecki Aleksandra, El-Sabban Marwan E, Rath Mathias. Ascorbic acid induces apoptosis in adult T-cell leukemia.. Anticancer research. 2007.

Предметные рубрики MeSH

Apoptosis Ascorbic Acid Cell Cycle Cell Growth Processes Cyclin-Dependent Kinase Inhibitor p21 Enzyme-Linked Immunosorbent Assay Flow Cytometry HTLV-I Infections Human T-lymphotropic virus 1 Humans Jurkat Cells Leukemia-Lymphoma, Adult T-Cell Proto-Oncogene Proteins c-bcl-2 Transforming Growth Factors Tumor Suppressor Protein p53 bcl-2-Associated X Protein

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