PET/CT Identifies Pubic Melorheostosis with High 68Ga-PSMA Uptake in a Patient with Prostate Cancer.

Melorheostosis, a rare benign bone disorder marked by cortical thickening and irregular hyperostosis, typically affects peripheral bones but can also involve the axial skeleton. Though various molecular imaging radiotracers have been used to evaluate this condition, there are no previous reports of positive 68Ga-prostate-specific membrane antigen positron emission tomography/computed tomography (68Ga-PSMA PET/CT) findings in melorheostosis. This case presents a 70-year-old man with metastatic prostate cancer whose 68Ga-PSMA PET/CT scan revealed intense 68Ga-PSMA uptake in pubic melorheostosis seen on magnetic resonance imaging. The case highlights the possibility of 68Ga-PSMA-avid melorheostosis and suggests 68Ga-PSMA PET/CT may have a role in the evaluation of melorheostosis.