Early human development · 2026
Lean mass to soft tissue ratio in Chinese fetuses: A novel predictor of congenital myopathy.
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Zeng Xiao-Jing, Jiang Yu-Ting, Zheng Qiao, Lei Ting, Xie Hong-Ning
Аннотация
OBJECTIVE: To establish a normal reference interval for the mid-thigh lean mass (MTLM) and mid-thigh soft tissue (MTST) ratio (LMSTr) between 20 and 32 weeks of gestation in a Chinese cohort and to report the association between the abnormal LMSTr and congenital myopathies.
METHOD: Pregnant women with a singleton non anomalous pregnancy were prospectively recruited and underwent a normal scan at 20-32 weeks. We performed an inter- and intra-observer variability assessment in the measurement of MTLM and MTST in 50 patients. Reference ranges for LMSTr were calculated in the normal fetuses. The digital archives were also retrospectively searched to retrieve images of the fetal thigh from fetuses confirmed with congenital myopathy over a period of 3 years.
RESULTS: 430 cases fulfilling the inclusion criteria were prospectively included. The intra- and interobserver agreement was almost perfect. There was significant quadratic association between LMSTr and gestational age. Retrospective analysis of 6 congenital myopathy cases identified reduced LMSTr in 5 cases (83%).
CONCLUSION: Systematic assessment of the LMSTr in fetuses at 20-32 weeks of gestation is feasible, with good reproducibility in normal cases. Smaller values of LMSTr can be demonstrated in fetuses with congenital myopathies.
METHOD: Pregnant women with a singleton non anomalous pregnancy were prospectively recruited and underwent a normal scan at 20-32 weeks. We performed an inter- and intra-observer variability assessment in the measurement of MTLM and MTST in 50 patients. Reference ranges for LMSTr were calculated in the normal fetuses. The digital archives were also retrospectively searched to retrieve images of the fetal thigh from fetuses confirmed with congenital myopathy over a period of 3 years.
RESULTS: 430 cases fulfilling the inclusion criteria were prospectively included. The intra- and interobserver agreement was almost perfect. There was significant quadratic association between LMSTr and gestational age. Retrospective analysis of 6 congenital myopathy cases identified reduced LMSTr in 5 cases (83%).
CONCLUSION: Systematic assessment of the LMSTr in fetuses at 20-32 weeks of gestation is feasible, with good reproducibility in normal cases. Smaller values of LMSTr can be demonstrated in fetuses with congenital myopathies.