Retina (Philadelphia, Pa.) · 2026
CONTRAST SENSITIVITY FUNCTION CORRELATES WITH OPTICAL COHERENCE TOMOGRAPHY FINDINGS IN MACULAR TELANGIECTASIA TYPE 2.
СтатьяНаблюдательное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Finn Matthew J, Romano Francesco, Stettler Isabella, Garcia Mauricio D, Vingopoulos Filippos, Choi Hanna, Baldwin Grace, Bannerman Augustine, Ntentakis Dimitrios, Garg Itika, Razavi Peyman, Ding Xinyi, Bennett Cade F, Overbey Katherine M, Ploumi Ioanna, Katz Raviv, Patel Nimesh A, Kim Leo A, Vavvas Demetrios G, Husain Deeba, Miller Joan W, Miller John B
Аннотация
PURPOSE: To investigate the quantitative contrast sensitivity function (qCSF) changes in macular telangiectasia type 2 eyes and to assess associations with structural optical coherence tomography biomarkers.
METHODS: Cross-sectional, observational study including 49 macular telangiectasia type 2 eyes and 277 propensity score matched control eyes with same-day visual acuity, qCSF testing, and multimodal retinal imaging. Quantitative contrast sensitivity function metrics included area under the logarithm of contrast sensitivity function, contrast acuity, and contrast sensitivity thresholds at 1 to 18 cycles per degree. Structural optical coherence tomography biomarkers comprised presence and location of ellipsoid zone discontinuity, outer retinal hyperreflectivity, outer retinal cavitations, as well as macular neovascularization presence.Mixed-effects linear regression models, adjusted for age and lens status, compared the macular telangiectasia type 2 and the control groups and explored relationships with optical coherence tomography biomarkers.
RESULTS: Macular telangiectasia type 2 eyes showed significantly lower qCSF-measured contrast sensitivity than controls (β*: -1.28 to -0.78; all P < 0.001) for all analyzed qCSF metrics. Multivariable analysis revealed significant associations between reduced contrast sensitivity and structural biomarkers (β*: -1.03 to -0.51; all P < 0.05), except for macular neovascularization ( P > 0.05).
CONCLUSION: Our findings indicate that qCSF testing can identify reduced contrast sensitivity in macular telangiectasia type 2 across various spatial frequencies compared with controls. These changes seem particularly associated with early structural optical coherence tomography alterations.
METHODS: Cross-sectional, observational study including 49 macular telangiectasia type 2 eyes and 277 propensity score matched control eyes with same-day visual acuity, qCSF testing, and multimodal retinal imaging. Quantitative contrast sensitivity function metrics included area under the logarithm of contrast sensitivity function, contrast acuity, and contrast sensitivity thresholds at 1 to 18 cycles per degree. Structural optical coherence tomography biomarkers comprised presence and location of ellipsoid zone discontinuity, outer retinal hyperreflectivity, outer retinal cavitations, as well as macular neovascularization presence.Mixed-effects linear regression models, adjusted for age and lens status, compared the macular telangiectasia type 2 and the control groups and explored relationships with optical coherence tomography biomarkers.
RESULTS: Macular telangiectasia type 2 eyes showed significantly lower qCSF-measured contrast sensitivity than controls (β*: -1.28 to -0.78; all P < 0.001) for all analyzed qCSF metrics. Multivariable analysis revealed significant associations between reduced contrast sensitivity and structural biomarkers (β*: -1.03 to -0.51; all P < 0.05), except for macular neovascularization ( P > 0.05).
CONCLUSION: Our findings indicate that qCSF testing can identify reduced contrast sensitivity in macular telangiectasia type 2 across various spatial frequencies compared with controls. These changes seem particularly associated with early structural optical coherence tomography alterations.