Effect of intraovarian Platelet Rich Plasma injection during hysterectomy on ovarian reserve and sexual life.

OBJECTIVES

Low ovarian reserve is a major concern as older women seek pregnancy. Women 35 and older who want to conceive have fewer high-quality oocytes, which is linked to a drop in Anti-Müllerian Hormone (AMH). Women in this age bracket may need hysterectomy for abnormal uterine bleeding, leiomyomas, and pre-/malignant reasons. Those with preserved ovaries after hysterectomy nevertheless experience menopause. This circumstance impacts women's sexuality. Interventions to improve ovarian function in this age group may illuminate both concerns.

MATERIAL AND

METHODS

We did an observational case-control study of 35-50-year-old individuals who had hysterectomy for a benign disease. The trial group received perioperative PRP for their ovaries, while the control group received no treatment. Patients' preoperative AMH and Female Sexual Function Index (FSFI) scores were compared to those 3 months following surgery.

RESULTS

Our study found a substantial drop in postoperative AMH levels in the control group (p < 0.001), whereas the PRP group showed a slight increase in AMH levels. The PRP group has a significant difference in preoperative and postoperative AMH levels (p = 0.0001). The PRP group had a much higher total FSFI score. Subgroup analysis shows this variation in lubrication, orgasm, contentment, and pain. The PRP group had substantial differences in orgasm, pleasure, and pain pre- and post-operation.

CONCLUSIONS

PRP supports ovarian regeneration but has limited benefits. This information should be used to build standardized PRP protocols and undertake more extensive investigations by applying PRP to numerous organs, including the ovaries.