The Role of Decolonization in Prevention of Staphylococcus aureus Infection.

Staphylococcus aureus is a common skin commensal with significant pathogenic potential. S aureus is a leading cause of healthcare-associated infections, such as central-line associated bloodstream infections and surgical site infections, as well as skin and soft tissue infections. S aureus colonization is a significant risk factor for subsequent infection; thus, surveillance and decolonization with topical antimicrobials and antiseptics remain the mainstay of prevention. However, widespread implementation of decolonization protocols in hospitals and the community has been associated with antimicrobial resistance and microbiome perturbation. Thus, novel methods of S aureus decolonization and prevention remain a public health priority.