[The effect of natural and synthetic antioxidants on the profile of the parietal pH of the digestive tract in rats under normal and pathologic conditions].

The effect of natural (alpha-tocopherol) and synthetic (Dibunol and VN-3) antioxidants on H+ ion concentration in paramucous layer (PpH) of gut, duodenum, caecum, jejunum, and rectum in normal and vagotomized rats has been estimated 7, 14, and 30 days after introduction of the drugs. Vagotomy leads to transformation of the PpH shape of digestive tract. The effect is most pronounced at 7 days and reveals itself as an increase in PpH in gut, the decrease in PpH in duodenum and caecum. Introduction of E vitamin for 7 days led to the decrease in gut PpH and the increase in duodenum PpH in both groups of animals. Dibunol and VN-3 did not exert significant influence on the PpH of digestive tract of normal and vagotomized rats. An inhibitory effect of VN-3 on gut contractile activity in both groups of animals has been observed.