Pancreas · 2015
Validation of a nomogram for predicting the probability of carcinoma in patients with intraductal papillary mucinous neoplasm in 180 pancreatic resection patients at 3 high-volume centers.
СтатьяМногоцентровое исследованиеВалидационное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Shimizu Yasuhiro, Yamaue Hiroki, Maguchi Hiroyuki, Yamao Kenji, Hirono Seiko, Osanai Manabu, Hijioka Susumu, Kanemitsu Yukihide, Sano Tsuyoshi, Senda Yoshiki, Bhatia Vikram, Yanagisawa Akio
Аннотация
OBJECTIVE: We previously published a nomogram for prediction of carcinoma in patients with intraductal papillary mucinous neoplasm (IPMN). The objective of the current study was to validate this nomogram in an external cohort of patients at multiple institutions.
METHODS: The clinical details of 180 patients with IPMN who underwent a pancreatic resection at 3 hospitals were collected. Four significant predictive factors (sex, lesion type, nodule height, and pancreatic juice cytology) were analyzed.
RESULTS: Of the 180 patients, 66 (36.7%) had a main pancreatic duct-type IPMN and 114 (63.3%) had a branch pancreatic duct-type IPMN. The final pathological diagnosis was benign IPMN in 95 (52.8%) patients and malignant IPMN in 85 (47.2%) patients. The area under the receiver operating characteristic curve for the model was 0.760. The area under the receiver operating characteristic curve of the IPMN nomogram for prediction of malignancy was 0.747 in main pancreatic duct-type IPMN and 0.752 in branch pancreatic duct-type IPMN. The sensitivity and specificity of the model were 80.0% and 57.9%, respectively, when the predictive probability of more than 10% was used to indicate the presence of carcinoma.
CONCLUSIONS: This nomogram for predicting the probability of carcinoma in patients with IPMN was accurate in an external validation patient cohort.
METHODS: The clinical details of 180 patients with IPMN who underwent a pancreatic resection at 3 hospitals were collected. Four significant predictive factors (sex, lesion type, nodule height, and pancreatic juice cytology) were analyzed.
RESULTS: Of the 180 patients, 66 (36.7%) had a main pancreatic duct-type IPMN and 114 (63.3%) had a branch pancreatic duct-type IPMN. The final pathological diagnosis was benign IPMN in 95 (52.8%) patients and malignant IPMN in 85 (47.2%) patients. The area under the receiver operating characteristic curve for the model was 0.760. The area under the receiver operating characteristic curve of the IPMN nomogram for prediction of malignancy was 0.747 in main pancreatic duct-type IPMN and 0.752 in branch pancreatic duct-type IPMN. The sensitivity and specificity of the model were 80.0% and 57.9%, respectively, when the predictive probability of more than 10% was used to indicate the presence of carcinoma.
CONCLUSIONS: This nomogram for predicting the probability of carcinoma in patients with IPMN was accurate in an external validation patient cohort.
Предметные рубрики MeSH
AgedArea Under CurveCarcinoma, Pancreatic DuctalCarcinoma, PapillaryDecision Support TechniquesEndosonographyFemaleHospitals, High-VolumeHumansJapanMaleMiddle AgedNeoplasms, Cystic, Mucinous, and SerousNomogramsPancreatectomyPancreatic JuicePancreatic NeoplasmsPredictive Value of TestsProbabilityROC CurveReproducibility of ResultsSex FactorsTomography, X-Ray Computed