Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2007
A method of producing carcinoma in upper aerodigestive tree and esophagus of the Syrian golden hamster using wounding and instillation of N-methylnitrosourea.
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Estensen Richard D, Anderson W Robert, Galbraith Arthur R, Hartle Donna E, Jordan Margaret M, Ondrey Frank G, Wattenberg Lee W
Аннотация
Details of a method for producing carcinoma of the aerodigestive tree of the Syrian golden hamster and the use of this model to evaluate putative agents for chemoprevention of these carcinomas are described. The method produces a majority of squamous carcinomas of the trachea and glottis that follow squamous metaplasia of respiratory epithelium. In addition, seen are adenocarcinomas arising in glands of the respiratory tree. Squamous carcinomas of the digestive epithelium arise in primary squamous epithelium. These tumors of digestive epithelium have a growth pattern that differs from that of the respiratory epithelium in that they grow and invade without filling the epithelial layer with tumor cells.
Предметные рубрики MeSH
AdenocarcinomaAnimalsAnticarcinogenic AgentsCarcinogensCarcinomaCarcinoma, Squamous CellChemopreventionCricetinaeDisease Models, AnimalEpitheliumEsophageal NeoplasmsGlottisLaryngeal NeoplasmsMesocricetusMetaplasiaMethylnitrosoureaMucous MembranePharyngeal NeoplasmsRespiratory MucosaTracheaTracheal Neoplasms