American journal of clinical oncology · 2012
Efficacy and tolerability of long-acting octreotide in the treatment of thymic tumors: results of a pilot trial.
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Longo Flavia, De Filippis Lucilla, Zivi Andrea, Vitolo Domenico, Del Signore Ester, Gori Bruno, Diso Daniele, Anile Marco, Venuta Federico, De Giacomo Tiziano, Coloni Camillo Furio
Аннотация
OBJECTIVES: Octreotide is a somatostatin analog, long-acting formulations of which have been used experimentally for the treatment of patients with invasive tumors and/or residual disease after conventional therapies. The objective of this retrospective study was to evaluate the efficacy of long-acting octreotide (Sandostatin LAR) for the treatment of thymic tumors, with a primary efficacy end point of progression-free survival.
METHODS: Between 1994 and 2010, 44 patients with thymic malignancies were evaluated. Twenty-seven patients underwent an OctreoScan, and 12 OctreoScan-positive patients were treated with long-acting octreotide at a dose of 20 mg, given as an intramuscular injection, every 2 weeks.
RESULTS: Treatment with long-acting octreotide gave the following results: 3 cases of partial response (25%), 5 cases of stable disease (42%), and 4 cases of progressive disease (33%), with an average progression-free survival of 8 months (range, 3 to 21). Treatment compliance and tolerability were good for all evaluated patients.
CONCLUSIONS: The results of this study confirm the somatostatin receptor as a valid target for the treatment of thymic malignancies. Overall, therapy with long-acting somatostatin analogs seems to be safe and effective.
METHODS: Between 1994 and 2010, 44 patients with thymic malignancies were evaluated. Twenty-seven patients underwent an OctreoScan, and 12 OctreoScan-positive patients were treated with long-acting octreotide at a dose of 20 mg, given as an intramuscular injection, every 2 weeks.
RESULTS: Treatment with long-acting octreotide gave the following results: 3 cases of partial response (25%), 5 cases of stable disease (42%), and 4 cases of progressive disease (33%), with an average progression-free survival of 8 months (range, 3 to 21). Treatment compliance and tolerability were good for all evaluated patients.
CONCLUSIONS: The results of this study confirm the somatostatin receptor as a valid target for the treatment of thymic malignancies. Overall, therapy with long-acting somatostatin analogs seems to be safe and effective.
Предметные рубрики MeSH
AdultAgedAntineoplastic Agents, HormonalCarcinomaDelayed-Action PreparationsDisease-Free SurvivalDrug Administration ScheduleFemaleHumansIndium RadioisotopesInjections, IntramuscularMaleMiddle AgedNeoplasm Recurrence, LocalNeoplasm, ResidualOctreotidePilot ProjectsPositron-Emission TomographyResearch DesignRetrospective StudiesSample SizeSomatostatinThymus NeoplasmsTomography, X-Ray ComputedTreatment Outcome