Scientific reports · 2013
Increased tissue levels of omega-3 polyunsaturated fatty acids prevents pathological preterm birth.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Yamashita Aki, Kawana Kei, Tomio Kensuke, Taguchi Ayumi, Isobe Yosuke, Iwamoto Ryo, Masuda Koji, Furuya Hitomi, Nagamatsu Takeshi, Nagasaka Kazunori, Arimoto Takahide, Oda Katsutoshi, Wada-Hiraike Osamu, Yamashita Takahiro, Taketani Yuji, Kang Jing X, Kozuma Shiro, Arai Hiroyuki, Arita Makoto, Osuga Yutaka, Fujii Tomoyuki
Аннотация
Omega-3 polyunsaturated fatty acids such as eicosapentaenoic acid (EPA) have anti-inflammatory effects. Preterm birth is an important problem in modern obstetrics and one of the main causes is an inflammation. We here showed that abundance of omega-3 fatty acids reduced the incidence of preterm birth induced by LPS with fat-1 mice, capable of converting omega-6 to omega-3 fatty acids. We also indicated that the gene expression of IL-6 and IL-1β in uteruses and the number of cervical infiltrating macrophages were reduced in fat-1 mice. The analyses of lipid metabolomics showed the high level of 18-hydroxyeicosapentaenoate in fat-1 mice, which was derived from EPA and was metabolized to anti-inflammatory product named resolvin E3 (RvE3). We finally showed that the administration of RvE3 to LPS-exposed pregnant wild type mice lowered the incidence of preterm birth. Our data suggest that RvE3 could be a potential new therapeutic for the prevention of preterm birth.