Медицинская библиотека · Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2013

[Expression of pin1 in endometrial carcinoma and its relation with PR].

Tian Yan, Zhang Yi, Yu Jingjing, Zhang Yu

СтатьяПоддержка исследования: вне правительства СШАПеревод пока не подготовлен

Аннотация

OBJECTIVE

To investigate the clinicopathologic significance of pin1 and PR in patients with endometrial adenocarcinoma.

METHODS

The expression of pin1 and PR were investigated by immunohistochemistry in a total of 50 endometrial adenocarcinoma specimens.

RESULTS

Pin1 was over expressed in 66% (33/50) of the cases. The expression rate decreased gradually with tumor differentiation(P<0.05). In addition, pin1 expression was negatively correlated with lymph node metastasis and invasive depth of myometrium. Moreover, pin1 was positively correlated with PR expression.

CONCLUSION

Our results suggest that pin1 may play important roles in the tumorigenesis and migration of endometrial cancer. Pin1 expression may be considered as a prognostic marker as PR in patients with endometrial cancer.

Для цитирования: Tian Yan, Zhang Yi, Yu Jingjing, Zhang Yu. [Expression of pin1 in endometrial carcinoma and its relation with PR].. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2013.

Предметные рубрики MeSH

Adult Biomarkers, Tumor Endometrial Neoplasms Female Humans Lymphatic Metastasis Middle Aged NIMA-Interacting Peptidylprolyl Isomerase Peptidylprolyl Isomerase Receptors, Progesterone Uterine Neoplasms

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