Journal of drugs in dermatology : JDD · 2026
Impact of Intermittent Fasting, Keto Diet vs Continuous Caloric Restriction on Psoriasis Severity: A Systematic Review and Meta-Analysis Protocol.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод в очереди
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Alqefari Ahmed N, Almutairi Hanadi M, Almohaimeed Mohammed Yousef, Aldossari Abdulelah Abdulhadi, Alqefari Ghaida, Alsaleam Abdullah, Alzolibani Abdullateef A, Alhameedy Meshal
Аннотация
BACKGROUND: Psoriasis is a chronic immune‑mediated inflammatory skin disease that is strongly associated with metabolic dysregulation and excess adiposity. Dietary strategies that reduce energy intake either by continuous daily caloric restriction (CCR) or time‑limited/periodic intake such as intermittent fasting (IF) or ketogenic diets (Keto) may improve psoriasis severity through weight loss, metabolic improvements, alterations in gut microbiota, and immune-metabolic effects.
OBJECTIVE: We aimed to compare the therapeutic effectiveness of IF, Keto, and CCR in reducing the severity of psoriasis.
METHODS: This study was designed as a systematic review and Meta Analysis. The clinical parameters such as psoriasis extent and outcome measures were evaluated at baseline at different follow up timeframes across studies. Outcome measures were assessed by changes in Psoriasis Area and Severity Index (PASI) scores, quality of life (dermatology life quality index [DLQI]), and metabolic scores.
RESULTS: There was a significant PASI decrease in Keto and CCR cohorts (10-25.6 kg weight loss) compared with IF (0-2kg weight loss). No serious adverse effects were recorded in all interventions.
LIMITATIONS: The major limitations were study heterogeneity, lack of head-to-head comparisons, and follow up.
CONCLUSION: CCR and Keto performed better than IF in managing psoriasis severity, suggesting personalized dietary routines as adjuncts to treatment.  .
OBJECTIVE: We aimed to compare the therapeutic effectiveness of IF, Keto, and CCR in reducing the severity of psoriasis.
METHODS: This study was designed as a systematic review and Meta Analysis. The clinical parameters such as psoriasis extent and outcome measures were evaluated at baseline at different follow up timeframes across studies. Outcome measures were assessed by changes in Psoriasis Area and Severity Index (PASI) scores, quality of life (dermatology life quality index [DLQI]), and metabolic scores.
RESULTS: There was a significant PASI decrease in Keto and CCR cohorts (10-25.6 kg weight loss) compared with IF (0-2kg weight loss). No serious adverse effects were recorded in all interventions.
LIMITATIONS: The major limitations were study heterogeneity, lack of head-to-head comparisons, and follow up.
CONCLUSION: CCR and Keto performed better than IF in managing psoriasis severity, suggesting personalized dietary routines as adjuncts to treatment.  .