The Hyperpolarization-Activated, Cyclic-Nucleotide (HCN) Ion Channel Inhibitors as Potential Therapy for Pain, CNS Disorders, Psychiatric Disorders, and Tinnitus.

The invention in this patent application relates to 1H-indazole derivatives represented herein by formula 1. These compounds are inhibitors of hyperpolarization activated cyclic-nucleotide (HCN) modulated ion channel activity, with a selectivity for the inhibition of HCN1/HCN2 isoforms over the HCN4 isoform. The compounds may provide methods for treating, inhibiting, or ameliorating inflammatory and/or neuropathic pain, CNS disorders, psychiatric disorders, mood disorders, and tinnitus.