Neurocritical care · 2011
Clinical diagnosis and successful treatment of inflammatory cerebral amyloid angiopathy.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Bernstein Richard A, Gibbs Michael, Hunt Batjer H
Аннотация
INTRODUCTION: Cerebral amyloid angiopathy is a major cause of lobar hemorrhage in older adults, and of microvascular ischemic disease. The rarest form of this disease is an inflammatory form causing seizures. It is important to recognize because the patients usually respond to a brief course of immunosuppression.
METHODS: Case report.
RESULTS: A 66-year-old man developed gradual cognitive decline, insidiously increasing headaches, and then had a likely seizure. MRI showed diffuse white matter edema, and innumerable superficial microhemorrhages characteristic of amyloid angiopathy. He was empirically treated with oral prednisone and an anticonvulsant. His symptoms improved and the white matter edema resolved over several months. ApoE genotype was 4/4, which is commonly found in inflammatory amyloid angiopathy.
CONCLUSIONS: Inflammatory cerebral amyloid angiopathy can be clinically diagnosed and treated without brain biopsy. Clinical diagnosis is important because of the good response to a brief course of steroids in most cases.
METHODS: Case report.
RESULTS: A 66-year-old man developed gradual cognitive decline, insidiously increasing headaches, and then had a likely seizure. MRI showed diffuse white matter edema, and innumerable superficial microhemorrhages characteristic of amyloid angiopathy. He was empirically treated with oral prednisone and an anticonvulsant. His symptoms improved and the white matter edema resolved over several months. ApoE genotype was 4/4, which is commonly found in inflammatory amyloid angiopathy.
CONCLUSIONS: Inflammatory cerebral amyloid angiopathy can be clinically diagnosed and treated without brain biopsy. Clinical diagnosis is important because of the good response to a brief course of steroids in most cases.
Предметные рубрики MeSH
AgedAnticonvulsantsApolipoprotein E4Brain EdemaCerebral Amyloid Angiopathy, FamilialDiffusion Magnetic Resonance ImagingDrug Therapy, CombinationGenotypeHumansImage Processing, Computer-AssistedImmunosuppressive AgentsLevetiracetamMagnetic Resonance ImagingMaleNeurologic ExaminationNeuropsychological TestsOccipital LobePiracetamPrednisoneTemporal Lobe