Effectiveness of Data-Driven Gating FDG PET/CT for Abdominal Region.

This study aimed to validate the effectiveness of MotionFree (MF) in the abdominal region using 2 different PET/CT scanners to determine how to use MF efficiently.

Methods

All 198 patients underwent respiratory-gated 18F-FDG PET/CT with MF. Imaging was performed using Discovery MI (DMI) and Discovery IQ (DIQ) PET/CT scanners, and all data were divided into 2 groups in each category (abdominal: upper and lower abdomen, lesion size, <20 mm and ≥20 mm; scanner group: DMI and DIQ). A physician assessed whether the respiratory motion artifacts were reduced with MF. The SUV change rate (ΔSUV) of 80 measurable lesions with and without MF was calculated. The relationship between the ΔSUVs and these groups was compared.

Results

Motion artifacts were reduced in 62 of 198 patients (31.3%) in the upper abdomen, in 1 of 198 patients (0.5%) in the lower abdomen, in 51 of 98 patients (52.0%) in the DMI, and in 12 of 100 patients (12.0%) in DIQ with MF. ΔSUVs were significantly higher in the upper abdomen than in the lower abdomen. ΔSUV was up to 58.3% in DMI and up to 47.6% in DIQ. ΔSUVs of lesions with a size of less than 20 mm were significantly higher than those with a lesion size of 20 mm or greater. Although DMI was more effective than DIQ in terms of motion artifacts, both DMI and DIQ have the potential to increase the SUV with MF. MF significantly reduced the respiratory motion artifacts and increased the SUV for lesions smaller than 20 mm in the upper abdomen.

Conclusion

MF reduced the motion artifacts in higher-spatial-resolution PET/CT images. In both PET/CT scanners, SUVs in lesions smaller than 20 mm and lesions in the upper abdomen increased significantly with MF. To use MF without increasing the acquisition time, it may be useful to apply it to the upper abdomen.